Affiliated Scientists:
E. Desmond Lee and Family Fund Professor
Email: swang@danforthcenter.org
Phone: (314) 578-1419
Fax: (314) 578-1519
RESEARCH INTEREST
Signal transduction processes in plant growth and stress responses; Lipid-mediated signaling; Regulation and function of phospholipases; Lipidomics and metabolic profiling; Metabolic engineering and oilseed quality
RESEARCH
Signal transduction in plant growth, development, and stress responses: Lipid-mediated signaling; Functional genomics of phospholipases; Metabolic profiling and lipidomics; Metabolic engineering
Research in my laboratory concerns signal transduction processes that regulate plant growth, development, and stress responses. My current research is grouped into four interrelated clusters:
I. Lipid-mediated signaling
II. Functional genomics of phospholipases
III. Metabolic profiling and lipidomics
IV. Metabolic engineering
One major focus in my laboratory is to understand the role of membrane lipids and phospholipases in signaling cascades. Specifically, we are interested in: i) identifying and characterizing enzymes that generate lipid messengers, ii) defining downstream targets of lipid signaling pathways, iii) elucidating the relationship and networks of different signaling processes in hormonal and stress responses, and iv) determining the physiological functions of lipid-mediated signaling. In addition, we are applying knowledge gained from the above studies to manipulating crop plants for improving stress tolerance and productivity. Integrated approaches of molecular biology, biochemistry, cell biology, stress physiology, functional genomics, and metabolomics are employed in our research.
SELECTED PUBLICATIONS
Zhang Y, Zhu H, Zhang Q, Li M, Yan M, Wang R, Wang L, Welti R, Zhang W, Wang X. 2009. Phospholipase D and phosphatidic acid mediates reactive oxygen species production in abscisic acid-promoted stomatal movements. Plant Cell Aug 18. [Epub ahead of print]
Hong Y, Devaiah SP, Bahn SC, Thamasandra BN, Li M, Welti R, Wang X. 2009. Phospholipase Dε and phosphatidic acid enhance Arabidopsis nitrogen signaling and growth. Plant Journal 58:376-387.
Li M, Hong Y, Wang X 2009. Phospholipase D- and phosphatidic acid-mediated signaling in plants. Biochem Biophys Acta 179:927-935.
Pan X, Wang X. 2009. Quantitative profiling of plant hormones by mass spectrometry. J. Chromatography B 877:2806-2813.
Hong Y, Zhang W, Wang X. 2009. Lipid signaling in plant response to hyperosmotic stress. Plant Cell Environ (invited review)
Zhang W, Wen B, Li W, Hong Y, Wang X 2009. Plant Phospholipase D. in 'Plant Lipid Signalling' Munnik T ed, Springer, Dordrecht, The Netherlands (in press)
Hong Y, Pan X, Welti R, Wang X. 2008.Phospholipase Da3 is involved in hyperosmotic responses in Arabidopsis. Plant Cell 20: 803-816.
Li W, Li M, Welti R, Wang X. 2008. Differential degradation of extraplastidic and plastidic lipids during freezing and post-freezing recovery in Arabidopsis thaliana. J Biol Chem. 283: 461-468.
Pan X, Welti R,Wang X 2008. Simultaneous quantification of phytohormones and related metabolites in crude plant extracts by liquid chromatography-electrospray tandem mass spectrometry. Phytochemistry 69:1773-1781.
Hong Y, Zheng S, Wang X 2008.Dual functions of phospholipase Da1 in plant response to drought. Molecular Plant 1: 262-269
Hong Y, Pan X, Welti R, Wang X. 2008.The effect of Phospholipase Da3 on Arabidopsis response to hyperosmotic stress and glucose. Plant Signaling & Behavior 3: 1-2.
Boss W, Lynch D, Wang X. 2008. Lipid-mediated signaling. Annual Plant Reviews 33, 202-243.
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